https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13368 Wed 11 Apr 2018 17:48:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43352 Thu 15 Sep 2022 15:32:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7505 Sat 24 Mar 2018 08:38:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21530 Sat 24 Mar 2018 07:50:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22692 Kpna1, Kpna2, Kpna3, Kpna4, Kpna6, Kpna7, Kpnb1, Ipo5 and Xpo1), all were expressed in the embryonic ovary with up-regulation of protein levels concomitant with meiotic entry for KPNA2, accompanied by the redistribution of the cellular localisation of KPNA2 and XPO1. In contrast, postnatal folliculogenesis revealed significant up-regulation of Kpna1, Kpna2, Kpna4, Kpna6 and Ipo5 and down-regulation of Kpnb1, Kpna7 and Xpo1 at the primordial to primary follicle transition. KPNAs exhibited different localisation patterns in both oocytes and granulosa cells during folliculogenesis, with three KPNAs – KPNA1, KPNA2 and IPO5 – displaying marked enrichment in the nucleus by antral follicle stage. Remarkably, varied subcellular expression profiles were also identified in isolated pre-ovulatory oocytes with KPNAs KPNA2, KPNB1 and IPO5 detected in the cytoplasm and at the nuclear rim and XPO1 in cytoplasmic aggregates. Intriguingly, meiotic spindle staining was also observed for KPNB1 and XPO1 in meiosis II eggs, implying roles for KPNAs outside of nucleo-cytoplasmic transport. Thus, we propose that KPNAs, by targeting specific cargoes, are likely to be key regulators of oocyte development.]]> Sat 24 Mar 2018 07:11:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46833 Mon 29 Jan 2024 18:41:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42361 Mon 14 Nov 2022 17:49:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55287 Fri 10 May 2024 16:22:11 AEST ]]>